Terminal sterilization is the sterilization of parenteral drug products in their final primary container. It requires tight control of time, temperature / F0, pressure, and heat transfer to achieve sterility without compromising product quality or container integrity. SteelcoBelimed terminal sterilizers support validated, repeatable processing using either steam-and-air mixture or superheated water, with load handling automation to sustain industrial throughput and reduce manual handling of heavy loads. For heat-sensitive formats such as BFS SVP and LVP, cycle development supports gentle processing adapted to container characteristics.
For steam-and-air mixture terminal sterilization, PST.2 process class 6060 provides a compact, modular solution, while AMS offers flexible layout and configuration for integrated installations and higher capacities. ASW is selected when superheated water processes are required, with flexible layout and configuration to match line integration and throughput needs.
Load handling automation complements terminal sterilization by improving efficiency, ergonomics, and repeatability, especially for heavy loads and high-volume operations.