Containment cleaning
in high-potent API production
Components used in high-potent API production such as parts from IBC systems, micronisers or milling machines can carry hazardous residues after processing. These items may require dismantling before cleaning and cannot be safely handled in open environments.
Containment cleaning is not just a washer function. It requires a complete containment architecture covering safe material transfers, controlled intervention, automated cleaning, waste handling and defined protocols for maintenance and service access.
Two implementation approaches
SteelcoBelimed provides two containment cleaning solutions designed for high-potent environments up to OEB 5. Both approaches maintain separation between contaminated and clean areas while enabling automated GMP cleaning.
Connected isolator
An isolator is connected to the loading side of the washer. Contaminated components are transferred into the isolator either through the washer chamber, which acts as a sluice between unloading and loading sides, or via a rapid transfer port for new items. Inside the isolator, components can be dismantled if required and placed onto the washer rack. The rack is transferred into the washer for automated wash, rinse and drying, then removed on the unloading side. The isolator remains closed during operation and waste can be removed safely via an RTP.
Integrated isolator
The washer chamber itself acts as the containment isolator. A side wall is fitted with a glass panel and glove ports, allowing safe intervention under containment conditions.
Components are transferred into the chamber in closed containers or bags. With the chamber sealed and operating under monitored negative pressure, the operator uses glove ports to position items onto the washer rack. Contaminated disposable parts are removed via a dedicated waste container. The automated cycle is executed and the cleaned rack is removed on the unloading side.
Components are transferred into the chamber in closed containers or bags. With the chamber sealed and operating under monitored negative pressure, the operator uses glove ports to position items onto the washer rack. Contaminated disposable parts are removed via a dedicated waste container. The automated cycle is executed and the cleaned rack is removed on the unloading side.
Designed for safe operation and service
Both solutions deliver contained GMP cleaning with the safeguards required for high-potent applications. During operation, components can be handled under containment where needed, with monitored negative pressure, filtered inlet and exhaust air, safe material transfers and segregation of contaminated effluents to a dedicated drain to protect operators and the environment.
For maintenance, defined cleaning and decontamination procedures are performed before opening the system, and safe filter change solutions minimize exposure during service interventions.
Related Products
PH 820.2/840.2/860.2
Modular, compact parts washer
